Open AccessTHE EFFECT OF X‐RAY INDUCED SYNCHRONY ON TWO‐DOSE CELL SURVIVAL EXPERIMENTS
Author(s) -
Young Judith M.,
Fowler John F.
Publication year - 1969
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1969.tb00996.x
Subject(s) - radiosensitivity , survival analysis , chinese hamster , cell survival , population , radiobiology , dose–response relationship , irradiation , radiation dose , hamster , biology , nuclear medicine , medicine , radiation therapy , pharmacology , physics , microbiology and biotechnology , genetics , cell culture , environmental health , nuclear physics
Calculations were made based on experimental data of the variation in radiosensitivity and in cell cycle delay with age in Chinese hamster cells (Sinclair, 1967, 1968). The computed syntheses included: (a) single‐dose survival curves; (b) splitdose recovery curves, the pattern of survival; and (c) two‐dose survival curves, the shape of the second survival curve. It is clear that, after an initial dose, changes occur in the subsequent dose‐response curve which depend upon size of dose and time after irradiation. Following rapid and apparently complete repair of sublethal injury, these changes can be attributed to progression of a partially synchronized population through phases of varying radiosensitivity. These changes may be small in some systems, but important in others. The concept of equal dose‐increments after each of several dose fractions is an over‐simplification and must be used with care.