Open AccessMEGAKARYOCYTOPOIESIS IN MICE
Author(s) -
Jr T. T. Odell,
Jr E. A. Burch,
Jackson C. W.,
Friday T. J.
Publication year - 1969
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1969.tb00245.x
Subject(s) - megakaryocytopoiesis , thymidine , megakaryocyte , biology , haematopoiesis , andrology , microbiology and biotechnology , medicine , biochemistry , stem cell , dna
Megakaryocytopoiesis was investigated in young RFM/Unf mice by determining in autoradiograms of marrow smears the labeling index (percentage of cells labeled) of morphologic stages of megakaryocytes at intervals after a single injection of tritiated thymidine. The total maturation time of recognizable megakaryocytes is estimated to be 50–57 hr. The average times spent in the Type I (immature) and Type II (mature) compartments are, respectively, 15 and 42 hr, but we believe that there is a wide variation in these periods among individual megakaryocytes. The frequencies of megakaryocytes of Types I, II and III are 10, 86 and 4%, respectively.