Open AccessHEPATOCYTIC PROLIFERATION IN NORMAL RATS AFTER MULTIPLE EXCHANGE TRANSFUSIONS WITH BLOOD FROM PARTIALLY HEPATECTOMIZED RATS
Author(s) -
Grisham J. W.
Publication year - 1969
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1969.tb00237.x
Subject(s) - washout , thymidine , dna synthesis , blood transfusion , andrology , medicine , biology , dna , biochemistry
Either three or four (but not one or two) consecutive exchange transfusions (75–85% washout of blood) of rats with intact livers, utilizing blood from donors partially hepatectomized 24 hr earlier, results in increased incorporation of 3 H‐thymidine into hepatic DNA and hepatocytic nuclei 20 hr after the first transfusion. Exchange transfusion with blood from sham‐hepatectomized animals does not produce this effect.