Open AccessBIOCHEMISTRY OF THE CELL CYCLE: A REVIEW
Author(s) -
Baserga Renato
Publication year - 1968
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1968.tb00957.x
Subject(s) - mitosis , dna synthesis , biology , dna replication , cell cycle , dna , microbiology and biotechnology , protein biosynthesis , mechanism (biology) , rna , replication (statistics) , cell , dna re replication , computational biology , biochemistry , gene , control of chromosome duplication , virology , philosophy , epistemology
This review describes the metabolic steps that occur in mammalian cells and that are related to the onset of DNA synthesis and mitosis. Two types of cells are considered separately: those continuously dividing and those that are quiescent but can be stimulated to enter DNA synthesis by appropriate stimuli. Despite the scarcity of data, a review of the literature suggests that the genome itself controls its own replication, and that this control is mediated through the synthesis of specific RNA and protein molecules. A similar mechanism is operating in the control of mitosis.