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Complex karyotype predicts for inferior outcomes following reduced‐intensity conditioning allogeneic transplant for chronic lymphocytic leukaemia
Author(s) -
Jaglowski Samantha M.,
Ruppert Amy S.,
Heerema Nyla A.,
Bingman Anissa,
Flynn Joseph M.,
Grever Michael R.,
Jones Jeffrey A.,
Elder Patrick,
Devine Steven M.,
Byrd John C.,
Andritsos Leslie A.
Publication year - 2012
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2012.09239.x
Subject(s) - cumulative incidence , cytogenetics , karyotype , medicine , chronic lymphocytic leukemia , oncology , transplantation , metaphase , incidence (geometry) , immunology , gastroenterology , leukemia , biology , chromosome , genetics , gene , physics , optics
Summary Complex karyotype ( CK ) on metaphase cytogenetics discriminates poor outcome in chronic lymphocytic leukaemia ( CLL ) patients undergoing salvage treatment; we hypothesized that it might provide prognostic information for patients undergoing allogeneic stem cell transplant. Fifty‐one CLL patients were analysed following transplant; 18‐month overall survival ( OS ), event‐free survival ( EFS ) and cumulative incidence of progression estimates were 35%, 14% and 63%, respectively, in patients with CK ( n = 19) versus 83%, 68% and 29% in patients without ( n = 32) ( P ≤ 0·0001, P ≤ 0·0001, and P = 0·02). In patients with high‐risk interphase cytogenetics, CK remained predictive of worse OS ( P = 0·02) and EFS ( P = 0·009). These findings support further evaluation of metaphase karyotype in transplant risk assessment.