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A functional polymorphism in the promoter region of the IL 1 B gene is associated with risk of multiple myeloma
Author(s) -
Vangsted Annette J.,
Nielsen Kaspar R.,
Klausen Tobias W.,
Haukaas Einar,
Tjønneland Anne,
Vogel Ulla
Publication year - 2012
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2012.09141.x
Subject(s) - haplotype , allele , multiple myeloma , confidence interval , immunology , interleukin 6 , gene , immune system , polymorphism (computer science) , relative risk , biology , genetics , medicine , microbiology and biotechnology , oncology , cytokine
Summary The cytokine interleukin‐1β ( IL 1 B ) is important for anti‐tumour immune response. Genetic variation may modify the expression of IL 1 B and thereby influence the risk of disease. We investigated genetic variations with functional importance in the IL 1 B and NFKB 1 genes in 348 population‐based samples of multiple myeloma ( MM ) and a random sample of 1700 individuals. Carriers of the variant T‐allele IL 1 B C ‐3737 T and carriers of the TGT haplotype were at lower risk of MM [relative risk ( RR ) 0·58 (95% confidence interval ( CI ) = 0·41–0·84) and RR 0·59 (95% CI 0·40–0·85), respectively]. No association with risk of MM was found for the NFKB 1 ‐ 94 ins/del polymorphism.