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Allogeneic Stem Cell Transplantation for Myelofibrosis in 2012
Author(s) -
McLornan Donal P.,
Mead Adam J.,
Jackson Graham,
Harrison Claire N.
Publication year - 2012
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2012.09107.x
Subject(s) - myelofibrosis , transplantation , medicine , stem cell , disease , population , hematopoietic stem cell transplantation , conditioning regimen , haematopoiesis , intensive care medicine , immunology , bone marrow , biology , environmental health , genetics
Summary Myelofibrosis ( MF ) is a heterogeneous disease for which long‐term, effective medical therapeutic options are currently limited. The role of allogeneic haematopoietic stem cell transplant ( AHSCT ) in this population, many of whom are elderly, often provides a challenge with regard to the identification of suitable candidates, timing of transplantation in the disease course and choice of conditioning regimen. This review summarizes key findings from published data concerning AHSCT in MF and attempts to provide a state of the art approach to MF ‐ AHSCT in 2012. In addition, we postulate on how the era of JAK inhibition might impact on transplantation for MF .