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How to manage invasive procedures in children with haemophilia
Author(s) -
Ljung Rolf C. R.,
Knobe Karin
Publication year - 2012
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2012.09089.x
Subject(s) - haemophilia , medicine , factor ix , haemophilia a , haemophilia b , intensive care medicine , risk factor , surgery , pediatrics
Summary Invasive procedures can be performed safely in children with haemophilia due to the availability of factor VIII / IX for patients without inhibitors. Most guidelines are based on the experiences in adults, but still there is no established consensus on the optimal factor levels or duration of replacement therapy for adults undergoing surgery. Few publications have focused on surgery in children with haemophilia. Children who have developed inhibitors to factor VIII / IX have to be treated with bypassing agents and constitute a group at higher risk for bleeding complications during surgery. The aim of this review is to summarize the experiences and opinions in the literature on replacement treatment of children with haemophilia, with and without inhibitors, during and after surgery, with a focus on the most prevalent clinical situations.