Premium
Increased prevalence of light chain monoclonal gammopathy of undetermined significance ( LC ‐ MGUS ) in first‐degree relatives of individuals with multiple myeloma
Author(s) -
Greenberg Alexandra J.,
Vincent Rajkumar S.,
Larson Dirk R.,
Dispenzieri Angela,
Therneau Terry M.,
Colby Colin L.,
Phelps Tara K.,
Kumar Shaji K.,
Katzmann Jerry A.,
Kyle Robert A.,
Slager Susan L.,
Vachon Celine M.
Publication year - 2012
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2012.09075.x
Subject(s) - monoclonal gammopathy of undetermined significance , proband , multiple myeloma , medicine , first degree relatives , population , gastroenterology , monoclonal , immunology , family history , monoclonal antibody , antibody , biology , genetics , mutation , environmental health , gene
Summary Previously, we reported increased risk of heavy‐chain ( HC ) monoclonal gammopathy of undetermined significance ( MGUS ) among first‐degree (1°) relatives of multiple myeloma ( MM ) or HC ‐ MGUS probands. This study investigated whether there was comparable risk for light‐chain ( LC ) MGUS among 911 relatives of the same HC ‐ MGUS / MM probands versus a reference population of 21 463. Seventeen 1° relatives had LC ‐ MGUS (adjusted prevalence = 1·7%, 95% CI = 0·9–2·6%). There was increased risk of LC ‐ MGUS in relatives of MM probands ( RR = 3·4, 95% CI = 2·0–5·5). We saw no increased risk in relatives of HC ‐ MGUS probands. We conclude that the prevalence of LC ‐ MGUS is significantly higher among 1° relatives of MM probands compared to the reference population.