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Genomic analysis of Non‐Splenic Marginal Zone Lymphomas (MZL) indicates similarities between nodal and extranodal MZL and supports their derivation from Memory B‐cells
Author(s) -
Novak Urban,
Basso Katia,
Pasqualucci Laura,
DallaFavera Riccardo,
Bhagat Govind
Publication year - 2011
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2011.08841.x
Subject(s) - marginal zone , splenic marginal zone lymphoma , nodal , biology , gene expression profiling , cell of origin , pathology , b cell , cell , gene , gene expression , medicine , genetics , antibody
Summary Three distinct categories of marginal zone lymphomas (MZLs) are currently recognized, principally based on their site of occurrence. They are thought to represent unique entities, but the relationship of one subtype with another is poorly understood. We investigated 17 non‐splenic MZLs (seven nodal, 10 extranodal) by gene expression profiling to distinguish between subtypes and determine their cell of origin. Our findings suggest biological inter‐relatedness of these entities despite occurrence at different locations and associations with possibly different aetiologies. Furthermore, the expression profiles of non‐splenic MZL were similar to memory B cells.