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Pulmonary function in thalassaemia major and its correlation with body iron stores
Author(s) -
Sohn Eugene Y.,
Noetzli Leila J.,
Gera Aakanksha,
Kato Roberta,
Coates Thomas D.,
Harmatz Paul,
Keens Thomas G.,
Wood John C.
Publication year - 2011
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2011.08808.x
Subject(s) - pulmonary function testing , medicine , correlation , function (biology) , cardiology , biology , mathematics , genetics , geometry
Summary This study compared pulmonary function tests (PFTs) with cardiac, pancreatic and liver iron in 76 thalassemia major (TM) patients. Restrictive lung disease was observed in 16%, hyperinflation in 32% and abnormal diffusing capacity in 3%. While no patients met Global Initiative for Chronic Lung Disease criteria for airways obstruction, there were indicators of small airways disease and air trapping. PFTs did not correlate with somatic iron burden, blood counts or haemolysis. Restrictive lung disease was associated with inflammation. We conclude that TM patients have pulmonary abnormalities consistent with small airways obstruction. Restrictive disease and impaired diffusion are less common.