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Elimination of blood group antigens: hope and reality
Author(s) -
Bagnis Claude,
Chiaroni Jacques,
Bailly Pascal
Publication year - 2011
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2010.08561.x
Subject(s) - economic shortage , transfusion medicine , interchangeability , medicine , blood group antigens , donation , blood donor , intensive care medicine , blood transfusion , immunology , blood supply , antigen , surgery , political science , computer science , law , linguistics , philosophy , government (linguistics) , programming language
Summary In transfusion medicine, three major issues, i.e. heterogeneity of human blood groups, dependence of blood supply on donation, and shortage of some phenotypes, oblige clinicians to juggle with available biological material to avoid or limit post‐transfusion reactions. This ‘fact of life’ has given impetus to a 30‐year‐old quest to achieve interchangeability of blood products between donors and recipients by eliminating blood group antigens.