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Antibody arrays identify protein‐protein interactions in chronic myeloid leukaemia
Author(s) -
Patel Hetal,
Nteliopoulos Georgios,
Nikolakopoulou Zacharoula,
Jackson Amanda,
Gordon Myrtle Y.
Publication year - 2011
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2010.08450.x
Subject(s) - chronic myeloid leukaemia , breakpoint cluster region , immunoprecipitation , antibody , myeloid leukemia , cancer research , biology , immunology , genetics , gene
Summary Multiprotein complex formation with p210 BCR‐ABL1 is likely to play a major role in determining cellular abnormalities in chronic myeloid leukaemia (CML). Although many p210 BCR‐ABL1 binding partners have been identified, it is likely that many have not. We evaluated the use of co‐immunoprecipitation and antibody arrays and found that this approach is capable of identifying new p210 BCR‐ABL1 binding partners, and may contribute to the search for new therapeutic targets in CML.