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review: Current status of stem cell mobilization
Author(s) -
Gertz Morie A.
Publication year - 2010
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2010.08313.x
Subject(s) - plerixafor , mobilization , stem cell , medicine , peripheral blood , transplantation , dosing , bone marrow , chemotherapy , oncology , intensive care medicine , cxcr4 , biology , inflammation , genetics , archaeology , history , chemokine
Summary New advances in effective mobilization of peripheral blood stem cells have permitted a greater proportion of patients to benefit from autologous stem cell transplantation. In this review, the relative merits of peripheral blood and mobilized bone marrow are discussed. All available agents are reviewed. A critical assessment of the appropriate dosing and frequency of available growth factors is undertaken, and the most commonly used chemotherapy plus growth factor combinations are covered. Specific recommendations for patients who are poor mobilizers are dealt with including the role of plerixafor.