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Verification that common variation at 2q37.1, 6p25.3, 11q24.1, 15q23, and 19q13.32 influences chronic lymphocytic leukaemia risk
Author(s) -
CrowtherSwanepoel Dalemari,
Mansouri Mahmoud,
Enjuanes Anna,
Vega Ana,
Smedby Karin E.,
RuizPonte Clara,
Jurlander Jesper,
Juliusson Gunnar,
Montserrat Emilio,
Catovsky Daniel,
Campo Elias,
Carracedo Angel,
Rosenquist Richard,
Houlston Richard S.
Publication year - 2010
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2010.08270.x
Subject(s) - chronic lymphocytic leukemia , allele , genotype , case control study , medicine , genome wide association study , single nucleotide polymorphism , immunology , genetics , oncology , biology , leukemia , gene
Summary A recent genome wide association study of chronic lymphocytic leukaemia (CLL) provided evidence that common variation at 2q13 (rs17483466), 2q37.1 (rs13397985), 6p25.3 (rs872071), 11q24.1 (rs735665), 15q23 (rs7176508) and 19q13.32 (rs11083846) affects CLL risk. To verify and further explore the relationship between these variants and CLL risk we genotyped case‐control datasets from Spain and Sweden (824 cases, 850 controls). Combined data provided statistically significant support for an association between genotypes at rs13397985, rs872071, rs735665, rs7176508 and rs11083846 and CLL risk. CLL risk increased with increasing numbers of risk alleles ( P trend = 1·40 × 10 −15 ), consistent with a polygenic model of disease susceptibility. These data validate the relationship between common variation and risk of CLL.