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Optimal management of chronic graft‐ versus ‐host disease in children
Author(s) -
Jacobsohn David A.
Publication year - 2010
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2010.08247.x
Subject(s) - medicine , graft versus host disease , incidence (geometry) , disease , complication , hematopoietic stem cell transplantation , chronic disease , transplantation , intensive care medicine , population , pediatrics , immunology , surgery , environmental health , optics , physics
Summary Chronic graft‐ versus ‐host disease (GVHD) is a major complication after allogeneic haematopoietic stem cell transplantation (HSCT). Not only is it the major cause of late mortality in HSCT patients, but it also accounts for significant morbidity. Much of the literature on chronic GVHD has focused on adults. Chronic GVHD is of major importance in children, especially since they have years to live following the complications of chronic GVHD and its therapy. The goal is to review incidence, manifestations, and therapies, especially when applicable to the paediatric population.