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Large scale screening for haemoglobin disorders in southern Vietnam: implications for avoidance and management
Author(s) -
O’Riordan Sean,
Hien Tran Tinh,
Miles Katie,
Allen Angela,
Quyen Nguyen Ngoc,
Hung Nguyen Quoc,
Anh Do Quang,
Tuyen Luc Nguyen,
Khoa Dao Bach,
Thai Cao Quang,
Triet Dao Minh,
Phu Nguyen Hoan,
Dunstan Sarah,
Peto Tim,
Clegg John,
Farrar Jeremy,
Weatherall David
Publication year - 2010
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2010.08237.x
Subject(s) - malaria , ethnic group , hemoglobinopathy , population , glucosephosphate dehydrogenase deficiency , medicine , environmental health , affect (linguistics) , demography , disease , biology , glucose 6 phosphate dehydrogenase , immunology , psychology , dehydrogenase , biochemistry , communication , sociology , anthropology , enzyme
Summary In order to obtain an approximate assessment of the public health burden that will be posed by the inherited disorders of haemoglobin in southern Vietnam, several thousand individuals were screened for these conditions. A smaller sample was screened for glucose‐6‐phosphate dehydrogenase (G6PD) deficiency. The important haemoglobin disorders identified were β thalassaemia, haemoglobin E and a variety of different forms of α thalassaemia. There were sufficient G6PD‐deficient individuals to materially affect malaria control programme design. The most remarkable finding was wide variation in the gene frequencies of these conditions among the ethnic groups sampled. The approximate number of babies expected to be born with clinically significant haemoglobin disorders in Vietnam was estimated from the gene‐frequency data. This study emphasizes the importance of wide‐scale population screening, including ethnic subgroups, to establish the requirements for inherited haemoglobin disorder programmes in resource‐limited settings.