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Diagnosis of post‐transplant lymphoproliferative disorder in solid organ transplant recipients – BCSH and BTS Guidelines
Author(s) -
Parker Anne,
Bowles Kristin,
Bradley J. Andrew,
Emery Vincent,
Featherstone Carrie,
Gupte Girish,
Marcus Robert,
Parameshwar Jayan,
Ramsay Alan,
Newstead Charles
Publication year - 2010
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2010.08161.x
Subject(s) - medicine , immunosuppression , lymphoproliferative disorders , post transplant lymphoproliferative disorder , hematology , transplantation , lymphoproliferative disease , solid organ , intensive care medicine , organ transplantation , guideline , disease , pediatrics , pathology , lymphoma , rituximab
Summary A joint working group established by the Haemato‐oncology subgroup of the British Committee for Standards in Haematology (BCSH) and the British Transplantation Society (BTS) has reviewed the available literature and made recommendations for the diagnosis and management of post‐transplant lymphoproliferative disorder (PTLD) in adult recipients of solid organ transplants. This review details the risk factors predisposing to development, initial features and diagnosis. It is important that the risk of developing PTLD is considered when using post transplant immunosuppression and that the appropriate investigations are carried out when there are suspicions of the diagnosis. These must include tissue for histology and computed tomography scan to assess the extent of disease. These recommendations have been made primarily for adult patients, there have been some comments made with regard to paediatric practice.