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Management of post‐transplant lymphoproliferative disorder in adult solid organ transplant recipients – BCSH and BTS Guidelines
Author(s) -
Parker Anne,
Bowles Kristin,
Bradley J. Andrew,
Emery Vincent,
Featherstone Carrie,
Gupte Girish,
Marcus Robert,
Parameshwar Jayan,
Ramsay Alan,
Newstead Charles
Publication year - 2010
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2010.08160.x
Subject(s) - medicine , immunosuppression , lymphoproliferative disorders , organ transplantation , hematology , solid organ , transplantation , chemotherapy , intensive care medicine , organ dysfunction , post transplant lymphoproliferative disorder , radiation therapy , guideline , surgery , pathology , lymphoma , rituximab , sepsis
Summary A joint working group established by the Haemato‐oncology subgroup of the British Committee for Standards in Haematology (BCSH) and the British Transplantation Society (BTS) has reviewed the available literature and made recommendations for the diagnosis and management of post‐transplant lymphoproliferative disorder in adult recipients of solid organ transplants. This review details the therapeutic options recommended including reduction in immunosuppression (RIS), transplant organ resection, radiotherapy and chemotherapy. Effective therapy should be instituted before progressive disease results in declining performance status and multi‐organ dysfunction. The goal of treatment should be a durable complete remission with retention of transplanted organ function with minimal toxicity.