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Alemtuzumab is safe and effective as immunosuppressive treatment for aplastic anaemia and single‐lineage marrow failure: a pilot study and a survey from the EBMT WPSAA
Author(s) -
Risitano Antonio Maria,
Selleri Carmine,
Serio Bianca,
Torelli Giovanni Fernando,
Kulagin Alexander,
Maury Sébastien,
Halter Jörg,
Gupta Vikas,
Bacigalupo Andrea,
Sociè Gerard,
Tichelli André,
Schrezenmeier Hubert,
Marsh Judith,
Passweg Jakob,
Rotoli Bruno
Publication year - 2010
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2009.08027.x
Subject(s) - alemtuzumab , medicine , regimen , aplastic anemia , bone marrow failure , pure red cell aplasia , gastroenterology , adverse effect , aplasia , immunology , bone marrow , toxicity , immunosuppression , oncology , transplantation , stem cell , haematopoiesis , biology , genetics
Summary An alemtuzumab‐based experimental immunosuppressive treatment (IST) regimen was investigated in 35 patients with severe aplastic anaemia (SAA), pure red cell (PRCA) or pure white cell aplasia (PWCA). Alemtuzumab total dose was 73–103 mg s.c., followed by cyclosporine. No serious toxicity due to the regimen was observed. Adverse events were clinically irrelevant; infectious events were rare. The total response rate was 58%, 84% and 100% in SAA, PRCA and PWCA, respectively, with corresponding 6 months cumulative response probabilities of 84%, 84% and 100%. Subcutaneous alemtuzumab is a feasible and sufficiently safe IST regimen for patients suffering from immune‐mediated marrow failures.