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Deciphering the molecular basis of venous thromboembolism: where are we and where should we go?
Author(s) -
Morange PierreEmmanuel,
Tregouet DavidAlexandre
Publication year - 2010
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2009.07975.x
Subject(s) - venous thromboembolism , medicine , disease , intensive care medicine , genetic predisposition , thrombosis
Summary Venous thromboembolism (VTE) is a frequent disease that has a major genetic component of risk. However, known identified genetic risk factors account for <30% of idiopathic (without any environmental origin) VTE cases. This article aims to review the lessons learnt during recent decades in the field of the genetics of VTE, describe the present state‐of‐art methods and discuss promising themes for finding new susceptibility loci.