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Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia
Author(s) -
Koppen Ilan J. N.,
Hermans Frederik J. R.,
Kaspers Gertjan J. L.
Publication year - 2010
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2009.07898.x
Subject(s) - methylenetetrahydrofolate reductase , mtrr , medicine , genetics , gene , genetic predisposition , oncology , snp , biology , single nucleotide polymorphism , allele , genotype
Summary Acute lymphoblastic leukaemia (ALL) is the most common paediatric cancer, accounting for nearly 30% of all paediatric cancers and 80% of childhood leukaemias. Polymorphisms in folate‐related genes may influence the susceptibility to childhood ALL. This review summarizes the results of 14 studies that focussed on the relationship between folate‐related gene polymorphisms and the susceptibility to ALL and that fulfilled certain quality criteria. The total group consisted of 729 children and 1821 adults or non age‐defined patients. The results of different studies sometimes contradict each other, for which there are several possible explanations. This includes an influence of the type of population studied, because there was a difference between Asian and European study results. Based on several studies, it is plausible that polymorphisms in the MTHFR gene, 677C>T and 1298A>C, are associated with a decreased susceptibility to childhood ALL in non‐Asian populations. Polymorphisms in other folate related genes ( MTRR , MTR [ MS ], TYMS [TS], SLC19A1 [ RFC1 ], NNMT , and SHMT1 ) are less clearly associated with susceptibility to ALL, and the number of included studies on this subject in this review is limited. Further investigations on the relevance of these polymorphisms need to be performed. In general, it is clear that susceptibility to (childhood) ALL is partly related to constitutional differences in folate gene polymorphisms.