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Prospective evaluation of haemoglobin oxygen saturation at rest and after exercise in paediatric sickle cell disease patients
Author(s) -
Campbell Andrew,
Minniti Caterina P.,
Nouraie Mehdi,
Arteta Manuel,
Rana Sohail,
Onyekwere Onyinye,
Sable Craig,
Ensing Gregory,
Dham Niti,
LuchtmanJones Lori,
Kato Gregory J.,
Gladwin Mark T.,
Castro Oswaldo L.,
Gordeuk Victor R.
Publication year - 2009
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2009.07854.x
Subject(s) - medicine , haemolysis , saturation (graph theory) , oxygen saturation , oxygen , cardiology , gastroenterology , immunology , chemistry , mathematics , organic chemistry , combinatorics
Summary Low steady state haemoglobin oxygen saturation in patients with sickle cell anaemia has been associated with the degree of anaemia and haemolysis. How much pulmonary dysfunction contributes to low saturation is not clear. In a prospective study of children and adolescents with sickle cell disease aged 3–20 years at steady state and matched controls, 52% of 391 patients versus 24% of 63 controls had steady state oxygen saturation <99% ( P < 0·0001), 9% of patients versus no controls had saturation <95% ( P = 0·008) and 8% of patients versus no controls had exercise‐induced reduction in saturation ≥3%. Decreasing haemoglobin concentration ( P ≤ 0·001) and increasing haemolysis ( P ≤ 0·003) but not pulmonary function tests were independent predictors of both lower steady‐state saturation and exercise‐induced reduction in saturation. Neither history of stroke nor history of acute chest syndrome was significantly associated with lower steady‐state oxygen saturation or exercise‐induced reduction in saturation. Tricuspid regurgitation velocity was higher in patients with lower steady state haemoglobin oxygen saturation ( P = 0·003) and with greater decline in oxygen saturation during the six‐minute walk ( P = 0·022). In conclusion, lower haemoglobin oxygen saturation is independently associated with increasing degrees of anaemia and haemolysis but not pulmonary function abnormalities among children and adolescents with sickle cell disease.