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Elevation of clonal serum free light chains in patients with HIV‐negative primary effusion lymphoma (PEL) and PEL‐like lymphoma
Author(s) -
De Filippi Rosaria,
Iaccarino Giancarla,
Frigeri Ferdinando,
Di Francia Raffaele,
Crisci Stefania,
Capobianco Gaetana,
Arcamone Manuela,
Becchimanzi Cristina,
Amoroso Barbara,
De Chiara Annarosaria,
Corazzelli Gaetano,
Pinto Antonio
Publication year - 2009
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2009.07846.x
Subject(s) - primary effusion lymphoma , lymphoma , medicine , effusion , human immunodeficiency virus (hiv) , immunoglobulin light chain , oncology , cancer research , pathology , immunology , antibody , surgery
Tumor necrosis factor receptor-associated factor 1 (TRAF1) is unique among the members of the TRAF family, as it lacks the N-terminal RING/zinc-finger domain. Also the function of TRAF1 is not clearly established, with many papers reporting contradictory results. Here we show that TRAF1 interacts with BAFF receptor, a member of the TNF receptor family, and positively regulates activation of the alternative NF-kappaB pathway. Ectopic expression of TRAF1 causes degradation of TRAF3, stabilization of NIK, and processing of p100 to produce the mature form p52. In addition, we show that knocking-down expression of TRAF1 in the Hodgkin's disease derived cell line L1236, interfere with p100 processing and with p52 mediate gene transcription. Collectively these results support a role for TRAF1 as a positive regulator of the NF-kappaB alternative pathway