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Cytogenetic abnormalities in multiple myeloma: poor prognosis linked to concomitant detection in random and focal lesion bone marrow samples and associated with high‐risk gene expression profile
Author(s) -
Zhou Yiming,
Nair Bijay,
Shaughnessy Jr John D,
Cartron MarieAstrid,
Haessler Jeff,
Anaissie Elias,
Van Rhee Frits,
Crowley John,
Barlogie Bart
Publication year - 2009
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2009.07670.x
Subject(s) - multiple myeloma , bone marrow , hazard ratio , medicine , concomitant , oncology , pathology , gastroenterology , confidence interval
Summary The clinical significance of cytogenetic abnormalities (CA) present in randomly sampled (RS) or focal lesion (FL) bone marrow sites was examined in 419 untreated myeloma patients. Among 290 patients with gene expression profiling (GEP) data generated from RS sites, GEP‐defined high‐risk was present in 52% of the RS+/FL+ group but in only 9% of the remainder ( P < 0·001). The RS+/FL+ constellation (18%) was an independent predictor of poor survival, also after adjusting for GEP‐derived risk and TP53 status (Hazard ratio = 2·42, P = 0·004). The prevalence of high‐risk myeloma in the RS+/FL+ group may reflect a dissemination‐prone condition not shared by the other three groups.