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Risk factors for high cerebral blood flow velocity and death in Kenyan children with Sickle Cell Anaemia: role of haemoglobin oxygen saturation and febrile illness
Author(s) -
Makani Julie,
Kirkham Fenella J.,
Komba Albert,
AjalaAgbo Tolulope,
Otieno Godfrey,
Fegan Gregory,
Williams Thomas N.,
Marsh Kevin,
Newton Charles R.
Publication year - 2009
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2009.07660.x
Subject(s) - medicine , kenya , cerebral blood flow , saturation (graph theory) , anemia , oxygen saturation , sickle cell anemia , pediatrics , immunology , oxygen , disease , biology , chemistry , ecology , organic chemistry , mathematics , combinatorics
Summary High cerebral blood flow velocity (CBFv) and low haemoglobin oxygen saturation (SpO 2 ) predict neurological complications in sickle cell anaemia (SCA) but any association is unclear. In a cross‐sectional study of 105 Kenyan children, mean CBFv was 120 ± 34·9 cm/s; 3 had conditional CBFv (170–199 cm/s) but none had abnormal CBFv (>200 cm/s). After adjustment for age and haematocrit, CBFv ≥150 cm/s was predicted by SpO 2 ≤ 95% and history of fever. Four years later, 10 children were lost to follow‐up, none had suffered neurological events and 11/95 (12%) had died, predicted by history of fever but not low SpO 2 . Natural history of SCA in Africa may be different from North America and Europe.