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Methotrexate and aminopterin exhibit similar in vitro and in vivo preclinical activity against acute lymphoblastic leukaemia and lymphoma
Author(s) -
Kang Min H.,
Harutyunyan Narine,
Hall Connor P.,
Papa Rachael A.,
Lock Richard B.
Publication year - 2009
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2009.07631.x
Subject(s) - methotrexate , antifolate , aminopterin , in vivo , medicine , lymphoma , pharmacology , lymphoblastic lymphoma , in vitro , chemotherapy , cancer research , antimetabolite , immunology , biology , biochemistry , t cell , microbiology and biotechnology , immune system
Summary Due to the development of neurological toxicity and resistance to methotrexate (MTX), other antifolates have been evaluated for its potential replacement in the treatment of childhood acute lymphoblastic leukaemia (ALL). Aminopterin (AMT) has been suggested to provide clinical advantages over MTX and other antifolates. AMT activity, compared with MTX, was evaluated in ALL and lymphoma preclinical models. The minimum survival fraction at the range of concentrations tested was lower with AMT than with MTX in 3 out of 15 cell lines. Both AMT and MTX significantly extended the event‐free survival of mice bearing 3 out of 4 xenografts with equivalent activity.