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Chronic transfusion practice for children with sickle cell anaemia and stroke
Author(s) -
Aygun Banu,
McMurray Marsha A.,
Schultz William H.,
Kwiatkowski Janet L.,
Hilliard Lee,
Alvarez Ofelia,
Heeney Matthew,
Kalinyak Karen,
Lee Margaret T.,
Miller Scott,
Helms Ronald W.,
Ware Russell E.
Publication year - 2009
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2009.07630.x
Subject(s) - medicine , stroke (engine) , pediatrics , sickle cell anemia , transfusion therapy , blood transfusion , intensive care medicine , disease , mechanical engineering , engineering
Summary Chronic transfusions to maintain haemoglobin S (HbS) ≤30% are the mainstay of treatment for children with sickle cell anaemia (SCA) and previous stroke. This HbS target is often hard to maintain, however, and values achieved in current practice are unknown. In preparation for the Phase III Stroke With Transfusions Changing to Hydroxyurea (SWiTCH) trial, we collected data on 295 children with SCA and stroke who received transfusions at 23 institutions. The overall average pre‐transfusion %HbS was 35 ± 11% (institutional range 22–51%). Receiving scheduled transfusions on time was the most predictive variable for maintaining HbS at the ≤30% goal.