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Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones
Author(s) -
Beer Philip A.,
Jones Amy V.,
Bench Anthony J.,
GodayFernandez Andrea,
Boyd Elaine M.,
Vaghela Krishna J.,
Erber Wendy N.,
Odeh Bassam,
Wright Christine,
McMullin Mary Frances,
Cullis Jonathan,
Huntly Brian J. P.,
Harrison Claire N.,
Cross Nicholas C. P.,
Green Anthony R.
Publication year - 2009
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2008.07560.x
Subject(s) - biology , genetics , somatic evolution in cancer , evolutionary biology , gene
Summary This study looked for clonal diversity in patients with a myeloproliferative neoplasm associated with more than one acquired genetic lesion. A tyrosine kinase mutation and a cytogenetic lesion were present in the same clone in six of seven patients. By contrast, the genetic lesions were present in separate clones in all six patients with two tyrosine kinase pathway mutations. Moreover, in two patients the clones were genetically unrelated by X‐chromosome inactivation studies. These data demonstrated clonal diversity in a subset of patients with early stage haematopoietic malignancy and showed, for the first time, that such clones may arise independently.