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CD4 + CD25 + FoxP3 + regulatory T cells are increased whilst CD3 + CD4 − CD8 − αβTCR + Double Negative T cells are decreased in the peripheral blood of patients with multiple myeloma which correlates with disease burden
Author(s) -
Feyler Sylvia,
Von LilienfeldToal Marie,
Jarmin Sarah,
Marles Lee,
Rawstron Andy,
Ashcroft A. J.,
Owen Roger G.,
Selby Peter J.,
Cook Gordon
Publication year - 2009
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2008.07530.x
Subject(s) - monoclonal gammopathy of undetermined significance , il 2 receptor , foxp3 , cd8 , t cell , immunology , immune system , bone marrow , cd3 , microbiology and biotechnology , medicine , biology , monoclonal antibody , antibody , monoclonal
Summary Increased levels of naturally occurring regulatory T cells (T Reg cells) have been found in a variety of solid tumours and haematological malignancies. In multiple myeloma (MM), evidence suggests that T Reg cells are increased though controversy exists with regards to their function and no relationship to disease stage and treatment has been demonstrated. Here, we demonstrate significantly elevated levels of functional CD4 + CD25 + FoxP3 + T Reg cells in a large cohort of patients with MM as well as monoclonal gammopathy of uncertain significance (MGUS) in comparison to age‐matched, healthy controls. The frequency of Double Negative T Reg cells was also evaluated, demonstrating that these cells were reduced in patients with MM. Furthermore, a characteristic profile of immunomodulatory cytokines in the peripheral blood and bone marrow of patients with MM and MGUS was demonstrated, compared with healthy controls. This data adds further evidence to the understanding of the role of T Reg cell subsets in tumour immunology and the fundamentals of the host/tumour immune conflict.