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Genome‐wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion
Author(s) -
Forconi Francesco,
Rinaldi Andrea,
Kwee Ivo,
Sozzi Elisa,
Raspadori Donatella,
Rancoita Paola M. V.,
Scandurra Marta,
Rossi Davide,
Deambrogi Clara,
Capello Daniela,
Zucca Emanuele,
Marconi Daniela,
Bomben Riccardo,
Gattei Valter,
Lauria Francesco,
Gaidano Gianluca,
Bertoni Francesco
Publication year - 2008
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2008.07373.x
Subject(s) - chronic lymphocytic leukemia , genome , locus (genetics) , medicine , genetics , biology , gene , oncology , leukemia
Summary Deletion of 17p ( TP53 ) identifies a rare subset of chronic lymphocytic leukaemia (17p‐ CLL) with aggressive behaviour. Genome‐wide DNA‐profiling was performed to investigate 18 patients with 17p‐ CLL. All cases had multiple copy‐number (CN) changes. Among the several recurrent CN changes identified, 8q24.13‐q24.1‐gain ( MYC ), 8p‐loss ( TNFRSF10A/B , also known as TRAIL1/2 ) and 2p16.1‐p14‐gain ( REL/BCL11A ) appeared frequently represented. 8p‐loss and 2p16.1‐p14‐gain also appeared clinically relevant and predicted significant shorter time from diagnosis to treatment (8p‐loss) and overall survival (8p‐loss and 2p16.1‐p14‐gain, P < 0·05). These observations document a highly unstable genome in 17p‐ CLL and suggest that additional genes outside the TP53 locus may be important for tumour behaviour.