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Double cord blood transplantation in patients with high risk bone marrow failure syndromes
Author(s) -
Ruggeri A.,
Peffault de Latour R.,
Rocha V.,
Larghero J.,
Robin M.,
Rodrigues C. A.,
Traineau R.,
Ribaud P.,
Ferry C.,
Devergie A.,
Gluckman E.,
Socié G.
Publication year - 2008
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2008.07364.x
Subject(s) - medicine , transplantation , cord blood , bone marrow , bone marrow transplantation , surgery
Summary Patients with bone marrow failure syndromes (BMFS) who reject a first allogeneic transplant or fail immunosuppressive therapy (IST) have an especially grim prognosis. We report 14 patients (eight adults, six children) transplanted with double cord blood transplantation (dUCBT) for BMFS. Neutrophil recovery was observed in eight patients, with full donor chimerism of one unit, and acute GVHD in 10. With a median follow‐up of 23 months, the estimated 2 years overall survival was 80 ± 17% and 33 ± 16% for patients with acquired and inherited BMFS, respectively. Transplantation of two partially HLA‐matched UCB thus enables salvage treatment of high‐risk patients with BMFS.