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Secondary non‐Hodgkin lymphoma (NHL) in children and adolescents after childhood cancer other than NHL
Author(s) -
Landmann Eva,
Oschlies Ilske,
Zimmermann Martin,
Moser Olga,
Graf Norbert,
Suttorp Meinolf,
Greiner Jeannette,
Reiter Alfred
Publication year - 2008
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2008.07356.x
Subject(s) - medicine , lymphoma , non hodgkin's lymphoma , lymphoblastic lymphoma , malignancy , cancer , confidence interval , pediatrics , childhood cancer , oncology , immunology , t cell , immune system
Summary The emergence of non‐Hodgkin lymphoma (NHL) during childhood and adolescence as a secondary neoplasm (SN) after previous cancer other than NHL is rare. To describe the characteristics and outcome of NHL following previous cancer other than NHL in children and adolescents, this study analysed the data of patients reported to the NHL‐Berlin‐Frankfurt‐Münster study centre from 1986 to 2005. Out of the total of 2968 NHL‐patients registered, 11 patients were assessed as having suffered from NHL as a proven SN. Four additional children had most likely suffered from NHL as an SN, but a late relapse of the first neoplasm could not be ruled out unequivocally. In the patients with proven SN, median age at diagnosis of the primary malignancy was 3·9 years (range 2–11·7). The median age at diagnosis of NHL was 7·6 years (range 4·7–18). Only lymphoblastic ( n = 7) and diffuse large B‐cell ( n = 4) lymphomas were diagnosed as SN. The estimated 5‐year event‐free survival from time of diagnosis of NHL was 91% [95% confidence interval (CI) 74–100%] in patients with proven SNs and 84% (95% CI 63–100%) when the patients with probable SNs were included in the analysis. We concluded that secondary NHL in children and adolescents confers a favourable prognosis.