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Detection of different clonal EBV strains in Hodgkin lymphoma and nasopharyngeal carcinoma tissues from the same patient
Author(s) -
Rey J.,
Xerri L.,
Bouabdallah R.,
Keuppens M.,
Brousset P.,
Meggetto F.
Publication year - 2008
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2008.07162.x
Subject(s) - nasopharyngeal carcinoma , lymphoma , epstein–barr virus , virus , pathogenesis , biology , gammaherpesvirinae , virology , gene , herpesviridae , polymerase chain reaction , disease , genome , cancer research , immunology , viral disease , medicine , pathology , genetics , radiation therapy
Summary The ubiquitous herpesvirus Epstein–Barr virus (EBV) is linked to the development of several malignancies, including nasopharyngeal carcinoma (UCNT) and Hodgkin lymphoma (HL). Despite the well‐known oncogenic properties of the EBV latent membrane protein 1 (LMP‐1), the different oncogenic pathways involved in the pathogenesis of each disease remain unclear. This study reported, for the first time, the case of a patient with sequential development of UCNT and HL. Polymerase chain reaction was used to determine the LMP‐1 gene sequence and demonstrate that the two tumours contained different clonal viral genomes, suggesting a central and specific role of EBV infection.