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Ocular adnexal lymphoma: no evidence for bacterial DNA associated with lymphoma pathogenesis
Author(s) -
Matthews Julie M.,
Moreno Lilliana I.,
Dennis Jeremy,
Byrne Gerald E.,
Ruiz Phillip,
Dubovy Sander R.,
Lossos Izidore S.
Publication year - 2008
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2008.07112.x
Subject(s) - chlamydia psittaci , pathogenesis , lymphoma , malt lymphoma , chlamydia , biology , polymerase chain reaction , chlamydiaceae , mucosa associated lymphoid tissue , immunology , chlamydia trachomatis , chlamydiales , pathology , medicine , genetics , gene
Summary Ocular Adnexal Lymphomas (OALs) are the most common tumors of the eye, the majority being extranodal mucosa‐associated lymphoid tissue (MALT) lymphomas. Association with Chlamydia psittaci was described in some geographic areas. OAL response to antibiotic therapy was reported in cases not harboring Chlamydia psittaci DNA, suggesting that other bacterial infection might be implicated in the pathogenesis. We examined 49 MALT OALs for bacterial DNA using two distinct polymerase chain reaction techniques based on universal bacterial primers. No bacterial DNA that could be implicated in OAL pathogenesis was detected, suggesting that bacterial infection is not associated with OAL in South Florida.