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Detection of elevated levels of tumour‐associated microRNAs in serum of patients with diffuse large B‐cell lymphoma
Author(s) -
Lawrie Charles H.,
Gal Shira,
Dunlop Heather M.,
Pushkaran Beena,
Liggins Amanda P.,
Pulford Karen,
Banham Alison H.,
Pezzella Francesco,
Boultwood Jacqueline,
Wainscoat James S.,
Hatton Christian S. R.,
Harris Adrian L.
Publication year - 2008
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2008.07077.x
Subject(s) - microrna , diffuse large b cell lymphoma , lymphoma , medicine , cancer , oncology , hematology , case control study , pathology , cancer research , biology , gene , biochemistry
Summary Circulating nucleic acids have been shown to have potential as non‐invasive diagnostic markers in cancer. We therefore investigated whether microRNAs also have diagnostic utility by comparing levels of tumour‐associated MIRN155 ( miR‐155 ), MIRN210 ( miR‐210 ) and MIRN21 ( miR‐21 ) in serum from diffuse large B‐cell lymphoma (DLBCL) patients ( n = 60) with healthy controls ( n = 43). Levels were higher in patient than control sera ( P = 0·009, 0·02 and 0·04 respectively). Moreover, high MIRN21 expression was associated with relapse‐free survival ( P = 0·05). This is the first description of circulating microRNAs and suggests that microRNAs have potential as non‐invasive diagnostic markers for DLBCL and possibly other cancers.