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Inferior outcomes for overweight children undergoing allogeneic stem cell transplantation
Author(s) -
Bulley Sean,
Gassas Adam,
Dupuis L. Lee,
Aplenc Richard,
Beyene Joseph,
Greenberg Mark L,
Doyle John J,
Sung Lillian
Publication year - 2008
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2007.06900.x
Subject(s) - overweight , stem cell , medicine , transplantation , pediatrics , oncology , obesity , biology , genetics
Summary This retrospective cohort study aimed at determining whether overweight children undergoing allogeneic stem cell transplantation (SCT) had inferior overall survival compared with children who were not overweight. Children ≥2 years of age who received allogeneic SCT were included. Overweight was defined as a body mass index ≥ 95th percentile; 54/325 (17%) children were overweight. Overall survival at 5 years was significantly inferior at 46·6 ± 7·3% in the overweight group compared with 59·5 ± 3·2% in the non‐overweight group ( P = 0·02). Our study demonstrated that overweight children who undergo allogeneic SCT had inferior survival compared with children who were not overweight.