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Molecular profiling of chronic lymphocytic leukaemia: genetics meets epigenetics to identify predisposing genes
Author(s) -
Plass Christoph,
Byrd John C.,
Raval Aparna,
Tanner Stephan M.,
De La Chapelle Albert
Publication year - 2007
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2007.06875.x
Subject(s) - epigenetics , profiling (computer programming) , disease , gene expression profiling , gene , chronic lymphocytic leukemia , molecular genetics , molecular diagnostics , molecular pathology , biology , bioinformatics , medicine , computational biology , genetics , leukemia , gene expression , pathology , computer science , operating system
Summary Molecular profiling may lead to a better understanding of a disease. This knowledge is especially important in malignancies, where multiple alterations are required during the progression from premalignant to malignant stages. Such information can be useful for the development of novel biomarkers that allow the prediction of a clinical course, response to treatment or early detection. Molecular data is also utilized to develop targeted therapies. Moreover, gene defects identified in profiling studies will help to understand the molecular pathways disrupted in the disease. This review provides an overview of molecular profiling approaches in chronic lymphocytic leukaemia (CLL). We will describe our current understanding of genetic alterations in CLL, the use of familial CLL for the identification of predisposing mutations, and the search for epigenetic alterations in CLL.