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Flexible and dynamic organization of bone marrow stromal compartment
Author(s) -
AnjosAfonso Fernando,
Bonnet Dominique
Publication year - 2007
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2007.06827.x
Subject(s) - mesenchymal stem cell , haematopoiesis , bone marrow , stromal cell , progenitor cell , stem cell , biology , compartment (ship) , microbiology and biotechnology , clinical uses of mesenchymal stem cells , immunology , stem cell transplantation for articular cartilage repair , cellular differentiation , cancer research , adult stem cell , genetics , oceanography , geology , gene
The bone marrow mesenchymal compartment contains putative stem/progenitors of skeletal tissue components such as bone, cartilage, haematopoiesis‐supporting stroma and adipocytes. Previously appreciated as vital to the support of haematopoiesis, these cells have also been recently recognized as having significant immunomodulatory properties with implications for allogeneic haematopoietic cell transplantation. Despite having been studied for more than three decades and currently being used in different clinical settings, their biology remains elusive. The aim of this review is to critically analyse the field of mesenchymal stem/progenitor cell biology, in respect of their relationship with other mesenchymal cell‐types. Several issues concerning lineage commitment and inter‐conversion potential between different mesenchymal cell‐types are reviewed.