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The human leucocyte antigen‐G 14‐basepair polymorphism correlates with graft‐versus‐host disease in unrelated bone marrow transplantation for thalassaemia
Author(s) -
La Nasa Giorgio,
Littera Roberto,
Locatelli Franco,
Lai Sara,
Alba Francesco,
Caocci Giovanni,
Lisini Daniela,
Nesci Sonia,
Vacca Adriana,
Piras Eugenia,
Bernardo Maria Ester,
CesareMerlone Alessandra Di,
Orrù Sandro,
Carcassi Carlo
Publication year - 2007
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2007.06779.x
Subject(s) - immunology , human leukocyte antigen , transplantation , bone marrow , biology , graft versus host disease , gene polymorphism , disease , medicine , antigen , gene , genotype , genetics
Summary The presence of the 14‐bp insertion polymorphism of the human leucocyte antigen (HLA)‐G gene ( HLA‐G ) promotes immune tolerance through increased synthesis of HLA‐G molecules. We investigated this polymorphism in a large cohort of 53 thalassaemia patients transplanted from an unrelated donor. Sixteen patients (30·2%) homozygous for the 14‐bp deletion had a higher risk of developing acute graft‐versus‐host disease (aGvHD) than patients homozygous for the 14‐bp insertion (−14‐bp/−14‐bp vs +14‐bp/+14‐bp: Relative Risk = 15·0; 95% confidence interval 1·59–141·24; P = 0·008). Therefore, the 14‐bp polymorphism could be an important predictive factor for aGvHD following bone marrow transplantation.