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A clinical score predicting a brief and uneventful course of newly diagnosed idiopathic trombocytopenic purpura in children
Author(s) -
Edslev Pernille Wendtland,
Rosthøj Steen,
Treutiger Iris,
Rajantie Jukka,
Zeller Bernward,
Jonsson Olafur G.
Publication year - 2007
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2007.06682.x
Subject(s) - medicine , thrombocytopenic purpura , purpura (gastropod) , pediatrics , platelet , scoring system , disease , ecology , biology
Summary The Nordic idiopathic thrombocytopenic purpura study data showed that morbidity occurred mainly in children with thrombocytopenia lasting >3 months, whereas, the risk period with platelet counts <20 × 10 9 /l was short and the number of bleeding events low in children with shorter disease duration. These brief, uneventful courses were predicted by developing a scoring system based on six clinical features: abrupt onset (weight 5), age <10 years (3), preceding infection (2), platelet count <5 × 10 9 /l, wet purpura (1) and male gender (1). The score was derived and validated in two different cohorts of children. High scores (10–14) clearly identified low‐risk patients. The score provides valid prognostic information and may be useful in clinical decision‐making.