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Prevalence and clinical characteristics of immune thrombocytopenic purpura in a cohort of monoclonal gammopathy of uncertain significance
Author(s) -
Rossi Davide,
Paoli Lorenzo De,
Franceschetti Silvia,
Capello Daniela,
Vendramin Chiara,
Lunghi Monia,
Conconi Annarita,
Magnani Corrado,
Gaidano Gianluca
Publication year - 2007
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2007.06633.x
Subject(s) - medicine , monoclonal gammopathy of undetermined significance , incidence (geometry) , thrombocytopenic purpura , confidence interval , cohort , monoclonal gammopathy , purpura (gastropod) , immune thrombocytopenia , immunopathology , immune system , immunology , monoclonal , monoclonal antibody , antibody , platelet , ecology , physics , optics , biology
Summary Monoclonal gammopathy of uncertain significance (MGUS) may become symptomatic for autoimmune manifestations. We report on the prevalence and clinical course of immune thrombocytopenic purpura (ITP) observed in a consecutive series of 228 MGUS patients. At MGUS diagnosis, ITP was determined in 6/228 cases, accounting for a prevalence of 2630/100 000 [95% confidence interval (CI): 1210–5620]. One incidental ITP case occurred after 21 months of follow‐up. After a follow‐up of 681·3 patient‐years, the crude incidence of ITP in MGUS was 146·8 per 100 000 patient‐year (95% CI: 3·7–817·8). Overall, these observations point to an association between MGUS and ITP.