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Association of bone marrow natural killer cell dose with neutrophil recovery and chronic graft‐versus‐host disease after HLA identical sibling bone marrow transplants
Author(s) -
Larghero Jerome,
Rocha Vanderson,
Porcher Raphael,
Filion Alain,
Ternaux Brigitte,
Lacassagne MarieNoelle,
Robin Marie,
Peffault de Latour Regis,
Devergie Agnes,
Biscay Nicole,
Ribaud Patricia,
Benbunan Marc,
Gluckman Eliane,
Marolleau Jean Pierre,
Socié Gerard
Publication year - 2007
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2007.06623.x
Subject(s) - bone marrow , medicine , immunology , natural killer cell , cd3 , cd34 , incidence (geometry) , human leukocyte antigen , univariate analysis , hazard ratio , graft versus host disease , cd8 , gastroenterology , immune system , transplantation , biology , antigen , stem cell , cytotoxic t cell , multivariate analysis , confidence interval , biochemistry , genetics , physics , optics , in vitro
Summary Allogeneic bone marrow (BM) transplant (BMT) outcomes have been correlated with the infused nucleated, CD34 + , and T‐ cell dose. The potential impact of natural killer (NK) BM infused cell dose has however not been established. We analysed the outcomes of 78 patients receiving an HLA identical BMT. A higher NK cell dose was associated with the speed of neutrophil ( P = 0·05) and platelet recovery ( P = 0·04). Higher nucleated cells, CD34 + , CD3 + , CD3 + /4 + , CD3 + /8 + and NK cell dose were associated with a lower incidence of chronic GvHD (cGvHD) in univariate analysis. In multivariate analysis, the risk of cGvHD was increased by a lower NK cell dose [hazard ratio (HR) = 2·3 (1·2–4·4) for cell dose <0·9 × 10 6 /kg; P = 0·01] and an older age [HR = 1·4 /10 years (1·1–1·8); P = 0·002]. In addition, a higher CD3 + /4 + and NK cell dose were associated with a decreased incidence of viral infections ( P = 0·03 and P = 0·06 respectively). No specific cell subpopulation infused dose was associated with survival. In conclusion, a higher BM NK cell dose is associated with an increased speed of neutrophil recovery and a decreased incidence of cGvHD.