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The expression of the novel cytotoxic protein granzyme M by large granular lymphocytic leukaemias of both T‐cell and NK‐cell lineage: an unexpected finding with implications regarding the pathobiology of these disorders
Author(s) -
Morice William G.,
Jevremovic Dragan,
Hanson Curtis A.
Publication year - 2007
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2007.06564.x
Subject(s) - granzyme , cytotoxic t cell , granzyme b , granzyme a , lineage (genetic) , cancer research , immunology , cell , biology , t cell , microbiology and biotechnology , chemistry , perforin , immune system , gene , genetics , in vitro
Summary Granzyme M (GrM) is a novel cytotoxic protein normally exclusively expressed by natural killer (NK)‐cells and cytotoxic T‐cells with innate immune function. As most T‐cell granular lymphocytic leukaemias (T‐LGL) are thought to be derived from the adaptive immune system it was predicted that T‐LGL would be GrM negative. Contrary to this hypothesis, bone marrow biopsy immunohistochemistry revealed that GrM was frequently expressed in both T‐LGL (16 / 18) and NK‐LGL (6 / 9). These unexpected results suggest commonality between T‐ and NK‐LGL, providing further support to the notion that T‐LGL is a disorder of dysregulated, chronically stimulated, adaptive cytotoxic T‐cells.