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Second transplant with two unrelated cord blood units for early graft failure after haematopoietic stem cell transplantation
Author(s) -
Fernandes Juliana,
Rocha Vanderson,
Robin Marie,
De Latour Régis Peffault,
Traineau Richard,
Devergie Agnès,
Ribaud Patricia,
Réa Delphine,
Larghero Jérôme,
Gluckman Eliane,
Socié Gérard
Publication year - 2007
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2007.06562.x
Subject(s) - haematopoiesis , transplantation , stem cell , cord blood , medicine , surgery , immunology , biology , genetics
Graft failure (GF) can be a fatal complication following haematopoietic stem cell transplantation (HSCT). We report four patients who developed early GF after unrelated HSCT and who subsequently received a double unrelated cord blood transplant (dUCBT) after reduced‐intensity conditioning, at a median 15 d after the decision to perform a second transplant. Neutrophil recovery was observed in all four patients between day +15 and +31 with full donor chimaerism of one unit. Acute GVHD grades II–IV was observed in three patients. Three are alive, between 12 and 25 months after dUCBT. In conclusion, dUCBT is a promising procedure to treat early GF.