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Outcomes of patients with haematological malignancies admitted to intensive care unit. A comparative review of allogeneic haematopoietic stem cell transplantation data
Author(s) -
Lim ZiYi,
Pagliuca Antonio,
Simpson Sylwia,
Cottam Simon,
Ervine Max,
Ho Aloysius Y. L.,
Devereux Stephen,
Mufti Ghulam J.
Publication year - 2007
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.06440.x
Subject(s) - medicine , intensive care unit , transplantation , hematopoietic stem cell transplantation , chemotherapy , stem cell , retrospective cohort study , haematopoiesis , surgery , genetics , biology
Summary The outcomes of 55 consecutive haemato‐oncology patients admitted to the intensive care unit (ICU) were retrospectively analysed. Twenty‐eight patients were admitted following haemopoietic stem cell transplantation (HSCT). Thirty‐nine patients were admitted with respiratory failure, and all patients required respiratory support. Seventeen patients survived to be discharged from ICU, with an actuarial 1‐year survival of 18%. Overall survival between patients who received intensive chemotherapy and those who underwent allogeneic HSCT was not significantly different (19% vs. 10%, P = 0·19). None of the nine myeloablative HSCT recipients survived (median survival: 9 d). Six of the 15 reduced‐intensity conditioned HSCT recipients survived beyond 1 year (median survival: 1050 d, range: 438–1437).