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Pro‐inflammatory bone marrow milieu in patients with chronic idiopathic neutropenia is associated with impaired local production of interleukin‐10
Author(s) -
Koumaki Vasiliki,
Damianaki Athina,
Ximeri Maria,
Pontikoglou Charis,
Axioti Fani,
Spanoudakis Michael,
Eliopoulos George D.,
Papadaki Helen A.
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.06345.x
Subject(s) - neutropenia , medicine , cytokine , bone marrow , immunology , interleukin , interleukin 6 , tumor necrosis factor alpha , inflammation , interleukin 8 , chemotherapy
Summary The levels of interleukin‐10 (IL‐10) were evaluated in long‐term bone marrow (BM) culture supernatants from 54 patients with chronic idiopathic neutropenia (CIN) and 30 healthy volunteers using enzyme‐linked immunoabsorbent assay. Cytokine levels were significantly reduced in patients, compared with controls, and strongly correlated with peripheral blood neutrophil counts. Low levels of supernatant IL‐10 were associated with increased values of supernatant IL‐1 β , tumour necrosis factor‐ α , IL‐6 and transforming growth factor‐ β 1 . We suggest that the pro‐inflammatory milieu in the BM of CIN patients may be causatively related to the impaired production of IL‐10, a cytokine normally displaying strong anti‐inflammatory properties.