Premium
Human leucocyte antigen‐C in B chronic lymphocytic leukaemia
Author(s) -
MontesAres Olga,
MoyaQuiles M. Rosa,
MontesCasado María,
GuerraPérez Natalia,
Campillo J. Antonio,
González Consuelo,
LópezBermejo Antonio,
Tamayo Manuel,
Majado M. Juliana,
Parrado Antonio,
Muro Manuel,
Marín Luis,
ÁlvarezLópez M. Rocío
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.06334.x
Subject(s) - immunology , chronic lymphocytic leukemia , medicine , antigen , leukemia
Summary This study aimed at characterising the distribution of human leucocyte antigen (HLA)‐C alleles in a large group of patients with B chronic lymphocytic leukaemia from Southeastern Spain. Ninety‐eight adult patients and 194 geographically and ethnically matched controls were studied. HLA‐C was determined by polymerase chain reaction sequence‐specific primers (PCR‐SSP) and PCR‐sequence‐specific oligonucleotides (SSO) methods. The HLA‐Cw*16 allele frequency was found to be significantly increased amongst patients compared with controls in our population (27·6% vs. 12·4%, P = 0·0012, Pc = 0·016). HLA‐C dimorphism was also analysed but no association was found.