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CD34 + stem cell top‐ups without conditioning after initial haematopoietic stem cell transplantation for correction of incomplete haematopoietic and immunological recovery in severe congenital immunodeficiencies
Author(s) -
Booth Claire,
Ribeil JeanAntoine,
Audat Françoise,
DalCortivo Liliane,
A Veys Paul,
J Thrasher Adrian,
Davies E. Graham,
Lefrère François,
Fischer Alain,
CavazzanaCalvo Marina,
Bobby Gaspar H.
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.06333.x
Subject(s) - haematopoiesis , stem cell , transplantation , immunology , hematopoietic stem cell transplantation , cd34 , medicine , biology , microbiology and biotechnology
Summary Haematopoietic stem cell transplantation can be limited by ineffective haematopoiesis and poor immune recovery. A CD34 + cell infusion without conditioning has the potential to improve stem cell function with limited toxicity. Eighteen patients with congenital immunodeficiencies received CD34 + boosts for various defects. When given <1 year after the original graft, six of seven cytopenic patients achieved transfusion independence. A second cohort ( n = 11) received boosts >1 year after the original graft; only minimal changes in immune function or chimaerism were noted. Unconditioned stem cell boosts have limited toxicity but should be given early after the original graft to be effective.