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Common gene expression signatures in t(8;21)‐ and inv(16)‐acute myeloid leukaemia
Author(s) -
Ichikawa Hitoshi,
Tanabe Kenji,
Mizushima Hiroshi,
Hayashi Yasuhide,
Mizutani Shuki,
Ishii Eiichi,
Hongo Teruaki,
Kikuchi Akira,
Satake Masanobu
Publication year - 2006
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2006.06310.x
Subject(s) - biology , gene , myeloid leukaemia , core binding factor , runx1 , gene expression , myeloid , transcription factor , microbiology and biotechnology , cancer research , genetics
Summary Human acute myeloid leukaemia (AML) involving a core‐binding factor (CBF) transcription factor is called CBF leukaemia. In these leukaemias, AML1 (RUNX1, PEBP2 α B, CBF α 2)‐MTG8 (ETO) and CBF β (PEBP2 β )‐MYH11 chimaeric proteins are generated by t(8;21) and inv(16) respectively. We analysed gene expression profiles of leukaemic cells by microarray, and selected genes whose expression appeared to be modulated in association with t(8;21) and inv(16). In a pair‐wise comparison, 15% of t(8;21)‐associated transcripts exhibited high or low expression in inv(16)‐AML, and 26% of inv(16)‐associated transcripts did so equivalently in t(8;21)‐AML. These common elements in gene expression profiles between t(8;21)‐ and inv(16)‐AML probably reflect the situation that AML1‐MTG8 and CBF β ‐MYH11 chimaeric proteins affect a common set of target genes in CBF leukaemic cells. On the other hand, 38% of t(8;21)‐associated and 24% of inv(16)‐associated transcripts were regulated in t(8;21)‐ and inv(16)‐specific manners. These distinct features of t(8;21)‐ and inv(16)‐associated genes correlate with the bimodular structures of the chimaeric proteins (CBF‐related AML1 and CBF β portions, and CBF‐unrelated MTG8 and MYH11 portions).